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Chapter 12: Variation

Form 5 Biology Bab 12: Variation

12.1 Types of Variation

Continuous vs. Discontinuous Variation

  • Continuous Variation: Variation showing a continuous spectrum of intermediate phenotypes between two extremes.
    • Characteristics: Quantitative, measurable, controlled by multiple genes (polygenic inheritance), and significantly influenced by environmental factors (e.g., height, weight, skin color, body mass index).
    • Graphical Representation: Normal distribution curve (bell-shaped curve).
  • Discontinuous Variation: Variation showing distinct, discrete phenotypic categories with no intermediate forms.
    • Characteristics: Qualitative, non-measurable, controlled by a single gene (monogenic) with two or three distinct alleles, and unaffected by environmental factors (e.g., ABO blood groups, presence of dimples, ability to roll tongue, earlobe type).
    • Graphical Representation: Discrete bar chart.

12.2 Causes of Variation

Genetic and Environmental Factors

  • Genetic Factors (Inherent Variation):
    • Meiosis - Crossing Over: Exchange of genetic material between non-sister chromatids of homologous chromosomes during Prophase I creates new allele combinations.
    • Meiosis - Independent Assortment: Random arrangement and segregation of homologous chromosome pairs at Metaphase I and Anaphase I produces diverse gametes.
    • Random Fertilization: Fusion between any random sperm cell and any random ovum yields unique zygotic combinations.
    • Gene and Chromosomal Mutations: Spontaneous permanent changes in DNA base sequences or chromosome structures/numbers introduce entirely new genetic traits.
  • Environmental Factors:
    • Sunlight exposure, nutrient intake, climate, water availability, and physical exercise influence phenotypic expression in continuous variation.
    • Environmental factors cannot alter an organism's underlying genotype or be inherited by offspring.

12.3 Mutation

Types of Mutations and Mutagens

  • Gene Mutation: Chemical changes in the nucleotide base sequence of a single gene.
    • Examples: Sickle cell anemia (base substitution altering hemoglobin beta chain), albinism, thalassemia, cystic fibrosis.
  • Chromosomal Mutation: Alteration in the structure or total number of whole chromosomes.
    • Changes in Structure: Deletion, duplication, inversion, translocation.
    • Changes in Number (Nondisjunction): Failure of homologous chromosomes or sister chromatids to separate during meiosis.
      • Down Syndrome: Trisomy 21 (47 chromosomes, $45 + XX$ or $45 + XY$).
      • Turner Syndrome: Monosomy X (45 chromosomes, $44 + XO$).
      • Klinefelter Syndrome: Extra X chromosome in males (47 chromosomes, $44 + XXY$).
  • Mutagens: Agents that induce or increase mutation rates.
    • Physical Mutagens: Ultraviolet (UV) light, X-rays, gamma radiation.
    • Chemical Mutagens: Benzene, formaldehyde, mustard gas, nitrous acid, nicotine, heavy metals.
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